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Article

Modified GFAP promoter auto-regulates tet-activator expression for increased transactivation and reduced tTA-associated toxicity.

Brain research. Molecular brain research - 30 May 2002

Barton Michael D, Dunlop J W, Psaltis G, Kulik J, DeGennaro L, Kwak Seung P

Abstract excerpt

Transactivator tTA is a necessary component of the tetracycline-regulated inducible gene system. While several transgenic animals have been described that express tTA in the central nervous system (CNS), their tTA levels are often limited, presumably due to toxic effects. We evaluated methods for auto-regulating tTA levels in astrocytes by modifying the transgenic promoter human GFAP (hGFAP). The hGFAP promoter...

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Source

Identifiers

PMID: 12007834
DOI: 10.1016/s0169-328x(02)00170-5

Genes

GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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