Article
Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth.
Molecular bioSystems - 1 Jul 2010
Huang Paul H, Miraldi Emily R, Xu Alexander M, Kundukulam Vibin A, Del Rosario Amanda M, Flynn Ryan A, Cavenee Webster K, Furnari Frank B, White Forest M
Abstract excerpt
To evaluate the role of individual EGFR phosphorylation sites in activating components of the cellular signaling network we have performed a mass spectrometry-based analysis of the phosphotyrosine network downstream of site-specific EGFRvIII mutants, enabling quantification of network-level effects of site-specific point mutations. Mutation at Y845, Y1068 or Y1148 resulted in diminished receptor phosphorylation,...
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