Article

EGFR upregulation drives signaling reactivation during EGFR inhibition in glioblastoma without broad kinome rewiring

2026-08-14

Abstract excerpt

<h4>Background: </h4> Epidermal growth factor receptor (EGFR) amplification occurs in ~50% of IDH-wildtype glioblastoma (GBM) cases, frequently accompanied by expression of the oncogenic EGFRvIII variant. Although EGFR represents an attractive therapeutic target, EGFR-directed therapies have shown limited clinical efficacy in GBM. Resistance to kinase inhibitors is frequently attributed to activation of compensato...

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Literature Corpus work: 7372aa12-9fd1-5637-b41f-1116999f3ce1
DOI: 10.64898/2026.08.13.744581

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