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Article

Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.

European journal of cancer (Oxford, England : 1990) - 1 May 2015

Erdem-Eraslan Lale, Gao Ya, Kloosterhof Nanne K, Atlasi Yassar, Demmers Jeroen, Sacchetti Andrea, Kros Johan M, Sillevis Smitt Peter, Aerts Joachim, French Pim J

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) is frequently mutated in various types of cancer. Although all oncogenic mutations are considered activating, different tumour types have different mutation spectra. It is possible that functional differences underlie this tumour-type specific mutation spectrum. METHODS: We have determined whether specific mutations in EGFR (EGFR, EGFRvIII and EGFR-L858R) have...

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Identifiers

PMID: 25754235
DOI: 10.1016/j.ejca.2015.02.006

Genes

EGFR
DOCK4
MYC
MYCBP2
SMTN
UGGT1

Variants

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