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Article

Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.

Journal of proteome research - 4 Mar 2011

Chumbalkar Vaibhav, Latha Khatri, Hwang YeoHyeon, Maywald Rebecca, Hawley Lauren, Sawaya Raymond, Diao Lixia, Baggerly Keith, Cavenee Webster K, Furnari Frank B, Bogler Oliver

Abstract excerpt

An in-frame deletion mutation in Epidermal Growth Receptor (EGFR), ΔEGFR is a common and potent oncogene in glioblastoma (GBM), promoting growth and survival of cancer cells. This mutated receptor is ligand independent and constitutively active. Its activity is low in intensity and thought to be qualitatively different from acutely ligand stimulated wild-type receptor implying that the preferred downstream...

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Identifiers

PMID: 21214269
DOI: 10.1021/pr101075e
PMCID: PMC3049961

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.PMID 21214269Read ↗

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