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Article

Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade.

Cancer research - 1 Jun 2010

Menashe Idan, Maeder Dennis, Garcia-Closas Montserrat, Figueroa Jonine D, Bhattacharjee Samsiddhi, Rotunno Melissa, Kraft Peter, Hunter David J, Chanock Stephen J, Rosenberg Philip S, Chatterjee Nilanjan

Abstract excerpt

Genome-wide association studies (GWAS) focus on relatively few highly significant loci, whereas less attention is given to other genotyped markers. Using pathway analysis to study existing GWAS data may shed light on relevant biological processes and illuminate new candidate genes. We applied a pathway-based approach to the breast cancer GWAS data of the National Cancer Institute (NCI) Cancer Genetic Markers of...

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Identifiers

PMID: 20460509
DOI: 10.1158/0008-5472.CAN-09-4502
PMCID: PMC2907250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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