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Pathway analysis for genome-wide genetic variation data: Analytic principles, latest developments, and new opportunities.

Journal of genetics and genomics = Yi chuan xue bao - 20 Mar 2021

Silberstein Micah, Nesbit Nicholas, Cai Jacquelyn, Lee Phil H

Abstract excerpt

Pathway analysis, also known as gene-set enrichment analysis, is a multilocus analytic strategy that integrates a priori, biological knowledge into the statistical analysis of high-throughput genetics data. Originally developed for the studies of gene expression data, it has become a powerful analytic procedure for in-depth mining of genome-wide genetic variation data. Astonishing discoveries were made in the...

Topics

Genetic Variation
Humans
Genome-Wide Association Study
Genomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33896739
DOI: 10.1016/j.jgg.2021.01.007
PMCID: PMC8286309

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