Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions.

doi:10.1093/hmg/ddv440

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Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions.

Human molecular genetics - 20 Dec 2015

Qian David C, Byun Jinyoung, Han Younghun, Greene Casey S, Field John K, Hung Rayjean J, Brhane Yonathan, Mclaughlin John R, Fehringer Gordon, Landi Maria Teresa, Rosenberger Albert, Bickeböller Heike, Malhotra Jyoti, Risch Angela, Heinrich Joachim, Hunter David J, Henderson Brian E, Haiman Christopher A, Schumacher Fredrick R, Eeles Rosalind A, Easton Douglas F, Seminara Daniela, Amos Christopher I

Abstract excerpt

Results from genome-wide association studies (GWAS) have indicated that strong single-gene effects are the exception, not the rule, for most diseases. We assessed the joint effects of germline genetic variations through a pathway-based approach that considers the tissue-specific contexts of GWAS findings. From GWAS meta-analyses of lung cancer (12 160 cases/16 838 controls), breast cancer (15 748 cases/18 084...

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Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions.

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