Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.

The Journal of cell biology - 19 Aug 2002

Urano Fumihiko, Calfon Marcella, Yoneda Takunari, Yun Chi, Kiraly Moni, Clark Scott G, Ron David

Abstract excerpt

The unfolded protein response (UPR) counteracts stress caused by unprocessed ER client proteins. A genome-wide survey showed impaired induction of many UPR target genes in xbp-1 mutant Caenorhabditis elegans that are unable to signal in the highly conserved IRE1-dependent UPR pathway. However a family of genes, abu (activated in blocked UPR), was induced to higher levels in ER-stressed xbp-1 mutant animals than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Endoplasmic Reticulum

Share to Helminth Proteins

Share to Membrane Glycoproteins

Share to Protein Folding

Share to Survival

Source

Open in PubMed Open full text

Identifiers

PMID: 12186849
DOI: 10.1083/jcb.200203086
PMCID: PMC2174003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.PMID 12186849Read ↗

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.Semantic proximity Read ↗

Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.Semantic proximity Read ↗

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.Semantic proximity Read ↗

An essential role for XBP-1 in host protection against immune activation in C. elegans.Semantic proximity Read ↗

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity.Semantic proximity Read ↗

Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka FishSemantic proximity Read ↗

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.Semantic proximity Read ↗

Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fishSemantic proximity Read ↗

The RIDD activity of <i>C. elegans</i> IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survivalSemantic proximity Read ↗

Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults.Semantic proximity Read ↗

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans.Semantic proximity Read ↗

The FOXO transcription factor DAF-16 bypasses ire-1 requirement to promote endoplasmic reticulum homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.