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Article

Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer.

Journal of biomedical science - 12 May 2010

Lin Ching-Hsiung, Yeh Kun-Tu, Chang Ya-Sian, Hsu Nicholas C, Chang Jan-Gowth

Abstract excerpt

Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are located within exons 18-21. The -216 single nucleotide polymorphism in the promoter region...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20459863
DOI: 10.1186/1423-0127-17-37
PMCID: PMC2875208

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20459863-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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