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Article

Capillary electrophoretic genotyping of epidermal growth factor receptor for pharmacogenomic assay of lung cancer therapy.

Journal of chromatography. A - 21 Sept 2012

Wang Chun-Chi, Chao Kun-Hsien, Chen Yen-Ling, Chang Jan-Gowth, Wu Shou-Mei

Abstract excerpt

In this research, a universal multiplex PCR method combining capillary gel electrophoresis was established for simultaneous analysis of mutations in exons 18-21 of EGFR kinase domain gene. After rinsing of the gel solution (1 × TBE buffer containing 2% HEC and 1.5% HPC), the diluted PCR sample was electrokinetically injected and separated at 35°C. Several parameters were investigated for method optimization,...

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Identifiers

PMID: 22901298
DOI: 10.1016/j.chroma.2012.07.087

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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