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Article

Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC.

Journal of experimental & clinical cancer research : CR - 16 May 2011

Dufort Sandrine, Richard Marie-Jeanne, Lantuejoul Sylvie, de Fraipont Florence

Abstract excerpt

BACKGROUND: Epidermal Growth Factor Receptor (EGFR) mutations, especially in-frame deletions in exon 19 (ΔLRE) and a point mutation in exon 21 (L858R) predict gefitinib sensitivity in patients with non-small cell lung cancer. Several methods are currently described for their detection but the gold standard for tissue samples remains direct DNA sequencing, which requires samples containing at least 50% of tumor...

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Identifiers

PMID: 21575212
DOI: 10.1186/1756-9966-30-57
PMCID: PMC3120717

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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