Article
Mutation profile of EGFR gene detected by denaturing high-performance liquid chromatography in Japanese lung cancer patients.
Journal of cancer research and clinical oncology - 1 Feb 2007
Sueoka Naoko, Sato Akemi, Eguchi Hidetaka, Komiya Kazutoshi, Sakuragi Toru, Mitsuoka Masahiro, Satoh Toshimi, Hayashi Shinichiro, Nakachi Kei, Sueoka Eisaburo
Abstract excerpt
PURPOSE: EGFR mutations in lung cancer increase sensitivity to an EGFR tyrosine kinase inhibitor, gefitinib. Mutation analysis of EGFR is essential for prediction of gefitinib response and avoidance of the coincidental severe side effects for the unresponsive population. The purpose of the presen...
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