Article
Reduced phosphorylation of the TGF-Beta signal transducer Smad2 in emphysematous human lung.
COPD - 1 Aug 2009
Leppäranta Outi, Myllärniemi Marjukka, Salmenkivi Kaisa, Kinnula Vuokko L, Keski-Oja Jorma, Koli Katri
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is characterized by inflammatory immune response, emphysematous destruction of alveolar structures and obstruction in the small conducting airways. Transforming growth factor (TGF)-beta is involved in the maintenance of normal lung tissue homeostasis as a regulator of extracellular proteolysis, tissue repair and inflammatory functions. This study was undertaken to...
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