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Article

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.

PloS one - 1 Jan 2011

Baarsma Hoeke A, Spanjer Anita I R, Haitsma Gertruud, Engelbertink Lilian H J M, Meurs Herman, Jonker Marnix R, Timens Wim, Postma Dirkje S, Kerstjens Huib A M, Gosens Reinoud

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by abnormal extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has been associated with abnormal ECM turnover in various chronic diseases. We determined WNT-pathway gene expression in pulmonary fibroblasts of individuals with and without COPD and disentangled the role of β-catenin in fibroblast phenotype...

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PMID: 21980461
DOI: 10.1371/journal.pone.0025450
PMCID: PMC3184127

Genes

DVL3

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