Article
JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.
Genetics - 1 Aug 2010
Deng Huai, Cai Weili, Wang Chao, Lerach Stephanie, Delattre Marion, Girton Jack, Johansen Jørgen, Johansen Kristen M
Abstract excerpt
The essential JIL-1 histone H3S10 kinase is a key regulator of chromatin structure that functions to maintain euchromatic domains while counteracting heterochromatization and gene silencing. In the absence of the JIL-1 kinase, two of the major heterochromatin markers H3K9me2 and HP1a spread in tandem to ectopic locations on the chromosome arms. Here we address the role of the third major heterochromatin...
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