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Article

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.

Nature - 15 Mar 1990

Reuter G, Giarre M, Farah J, Gausz J, Spierer A, Spierer P

Abstract excerpt

Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA
DNA-Binding Proteins
Dosage Compensation, Genetic
Drosophila
Heterochromatin
Metalloproteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphorylation

Pigmentation

Restriction Mapping

Suppression, Genetic

Source

Identifiers

PMID: 2107402
DOI: 10.1038/344219a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2107402-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.PMID 2107402Read ↗

JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.Semantic proximity Read ↗

Position effect variegation and chromatin proteins.Semantic proximity Read ↗

Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila.Semantic proximity Read ↗

Position-effect variegation in Drosophila depends on dose of the gene encoding the E2F transcriptional activator and cell cycle regulator.Semantic proximity Read ↗

Position effect variegation at fission yeast centromeres.Semantic proximity Read ↗

E(var)3-9 of Drosophila melanogaster encodes a zinc finger protein.Semantic proximity Read ↗

Dosage-dependent modification of position-effect variegation in Drosophila.Semantic proximity Read ↗

Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila.Semantic proximity Read ↗

Reduced DNA polytenization of a minichromosome region undergoing position-effect variegation in Drosophila.Semantic proximity Read ↗

Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.Semantic proximity Read ↗

A high proportion of genes involved in position effect variegation also affect chromosome inheritance.Semantic proximity Read ↗

Chromosomal structure is altered by mutations that suppress or enhance position effect variegation.Semantic proximity Read ↗

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