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Article

Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila.

Seminars in cell & developmental biology - 1 Feb 2003

Schotta Gunnar, Ebert Anja, Dorn Rainer, Reuter Gunter

Abstract excerpt

In position-effect variegation (PEV) genes become silenced by heterochromatisation. Genetic dissection of this process has been performed by means of dominant suppressor [Su(var)] and enhancer [E(var)] mutations. Selective genetic screens allowed mass isolation of more than 380 PEV modifier mutations identifying about 150 genes. Genetic fine structure studies revealed unique dosage dependent effects. Most of the...

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PMID: 12524009
DOI: 10.1016/s1084-9521(02)00138-6

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