Article
Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila.
Seminars in cell & developmental biology - 1 Feb 2003
Schotta Gunnar, Ebert Anja, Dorn Rainer, Reuter Gunter
Abstract excerpt
In position-effect variegation (PEV) genes become silenced by heterochromatisation. Genetic dissection of this process has been performed by means of dominant suppressor [Su(var)] and enhancer [E(var)] mutations. Selective genetic screens allowed mass isolation of more than 380 PEV modifier mutations identifying about 150 genes. Genetic fine structure studies revealed unique dosage dependent effects. Most of the...
Topics
- Animals
- Chromatin
- Drosophila
- Gene Silencing
- Heterochromatin
- Methyltransferases
- Mutation
- Phenotype