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Article

The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast.

Genetics - 1 Aug 2010

Rainey Meredith M, Korostyshevsky Daniel, Lee Sean, Perlstein Ethan O

Abstract excerpt

Numerous studies have shown that the clinical antidepressant sertraline (Zoloft) is biologically active in model systems, including fungi, which do not express its putative protein target, the serotonin/5-HT transporter, thus demonstrating the existence of one or more secondary targets. Here we show that in the absence of its putative protein target, sertraline targets phospholipid membranes that comprise the...

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Identifiers

PMID: 20457874
DOI: 10.1534/genetics.110.117846
PMCID: PMC2927751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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