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Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants

11 Mar 2020

Abstract excerpt

Sertraline hydrochloride is a commonly prescribed antidepressant medication that acts by amplifying serotonin signaling. Numerous studies have suggested that children of women taking sertraline during pregnancy have an increased risk of developmental defects. Resolving the degree of risk for human fetuses requires comprehensive knowledge of the pathways affected by this drug. We utilized a Drosophila melanogaster...

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PMID: 32161356
DOI: 10.1038/s41598-020-61362-y

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