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Article

Exploring an antifungal target in the plasma membrane H(+)-ATPase of fungi.

Biochimica et biophysica acta - 12 Jun 1997

Seto-Young D, Monk B, Mason A B, Perlin D S

Abstract excerpt

The plasma membrane H(+)-ATPase is a promising new antifungal target that is readily probed with the sulfhydryl-reactive reagent omeprazole. Inhibition of the H(+)-ATPase by omeprazole is closely linked to cell killing, and it has been suggested that enzyme inhibition may result from a covalent interaction within the first two transmembrane segments (M1 and M2) (Monk et al. (1995) Biochim. Biophys. Acta 1239,...

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Identifiers

PMID: 9218555
DOI: 10.1016/s0005-2736(97)00028-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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