Suppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast.

doi:10.1371/journal.pone.0119297

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Article

Suppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast.

PloS one - 1 Jan 2015

Alao John P, Weber Andrea M, Shabro Aidin, Sunnerhagen Per

Abstract excerpt

BACKGROUND: Potassium ion homeostasis plays an important role in regulating membrane potential and therefore resistance to cations, antibiotics and chemotherapeutic agents in Schizosaccharomyces pombe and other yeasts. However, the precise relationship between drug resistance in S. pombe and external potassium concentrations (particularly in its natural habitats) remains unclear. S. pombe can tolerate a wide...

Topics

Antifungal Agents
Antiporters
Cations
Drug Resistance, Fungal
Fungicides, Industrial
Mutation
Potassium Chloride
Saccharomyces cerevisiae Proteins
Schizosaccharomyces

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Identifiers

PMID: 25793410
DOI: 10.1371/journal.pone.0119297
PMCID: PMC4368599

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