Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy.

PloS one - 1 Jan 2012

Chen Jingqiu, Korostyshevsky Daniel, Lee Sean, Perlstein Ethan O

Abstract excerpt

Many antidepressants are cationic amphipaths, which spontaneously accumulate in natural or reconstituted membranes in the absence of their specific protein targets. However, the clinical relevance of cellular membrane accumulation by antidepressants in the human brain is unknown and hotly debated. Here we take a novel, evolutionarily informed approach to studying the effects of the selective-serotonin reuptake...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Autophagy
Share to Cell Membrane Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Fungal

Share to Intracellular Membranes

Share to Kinetics

Share to Lysosomes

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22529904
DOI: 10.1371/journal.pone.0034024
PMCID: PMC3329523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy.PMID 22529904Read ↗

The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast.Semantic proximity Read ↗

Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosisSemantic proximity Read ↗

Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.Semantic proximity Read ↗

Defects in intracellular trafficking and endocytic/vacuolar acidification determine the efficiency of endocytotic DNA uptake in yeast.Semantic proximity Read ↗

Exchangeable zinc ions transiently accumulate in a vesicular compartment in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.Semantic proximity Read ↗

ATP-binding cassette (ABC) transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the endoplasmic reticulum.Semantic proximity Read ↗

Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids.Semantic proximity Read ↗

Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and MembraneSemantic proximity Read ↗

Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.Semantic proximity Read ↗

Probing Endocytosis During the Cell Cycle with Minimal Experimental Perturbation.Semantic proximity Read ↗

Going with the Flow: Trafficking‐Dependent and ‐Independent Regulation of Serotonin TransportSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.