Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia.

Blood - 12 Aug 2010

Bies Juraj, Sramko Marek, Fares Joanna, Rosu-Myles Michael, Zhang Steven, Koller Richard, Wolff Linda

Abstract excerpt

Inactivation of p15INK4b, an inhibitor of cyclin-dependent kinases, through DNA methylation is one of the most common epigenetic abnormalities in myeloid leukemia. Although this suggests a key role for this protein in myeloid disease suppression, experimental evidence to support this has not been reported. To address whether this event is critical for premalignant myeloid disorders and leukemia development, mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p15
Share to Genes, myb

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Leukemia, Myeloid

Share to Monocytes

Share to Precancerous Conditions

Share to Retroviridae

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 20457873
DOI: 10.1182/blood-2009-08-238360
PMCID: PMC2924230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia.PMID 20457873Read ↗

p15Ink4b: Dual function in myelopoiesis and inactivation in myeloid diseaseSemantic proximity Read ↗

Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice.Semantic proximity Read ↗

The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemiaSemantic proximity Read ↗

Myb drives B-cell neoplasms and myeloid malignancies in vivoSemantic proximity Read ↗

Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemiaSemantic proximity Read ↗

Loss of FBXO9 enhances proteasome activity and promotes aggressiveness in acute myeloid leukemiaSemantic proximity Read ↗

PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression.Semantic proximity Read ↗

Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.Semantic proximity Read ↗

Aberrant methylation and impaired expression of the p15INK4b cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML)Semantic proximity Read ↗

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.Semantic proximity Read ↗

Identification of Chromatin Remodeling Genes Arid4a and Arid4b as Leukemia Suppressor GenesSemantic proximity Read ↗

Advances in the development of animal models of myeloid leukemias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.