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Article

Identification of Chromatin Remodeling Genes Arid4a and Arid4b as Leukemia Suppressor Genes

26 Aug 2008

Abstract excerpt

BACKGROUND: Leukemia evolves through a multistep process from premalignancy to malignancy. Epigenetic alterations, including histone modifications, have been proposed to play an important role in tumorigenesis. The involvement of two chromatin remodeling genes, retinoblastoma-binding protein 1 (Rbbp1/Arid4a) and Rbbp1-like 1 (Rbbp1l1/Arid4b), in leukemogenesis was not characterized. METHODS: The leukemic...

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PMID: 18728284
DOI: 10.1093/jnci/djn253

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