Article
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
The Journal of clinical investigation - 1 Apr 2011
Wartman Lukas D, Larson David E, Xiang Zhifu, Ding Li, Chen Ken, Lin Ling, Cahan Patrick, Klco Jeffery M, Welch John S, Li Cheng, Payton Jacqueline E, Uy Geoffrey L, Varghese Nobish, Ries Rhonda E, Hoock Mieke, Koboldt Daniel C, McLellan Michael D, Schmidt Heather, Fulton Robert S, Abbott Rachel M, Cook Lisa, McGrath Sean D, Fan Xian, Dukes Adam F, Vickery Tammi, Kalicki Joelle, Lamprecht Tamara L, Graubert Timothy A, Tomasson Michael H, Mardis Elaine R, Wilson Richard K, Ley Timothy J
Abstract excerpt
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). It is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic leukemia-retinoic acid receptor α (PML-RARA) fusion oncogene. Although this fusion oncogene is known to initiate APL in mice, other cooperating mutations, as yet ill defined, are important for disease pathogenesis. To identify...
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