Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment.

doi:10.1038/s41467-024-48124-4

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Article

Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment.

Nature communications - 1 May 2024

Bhattarai Kashi Raj, Mobley Robert J, Barnett Kelly R, Ferguson Daniel C, Hansen Baranda S, Diedrich Jonathan D, Bergeron Brennan P, Yoshimura Satoshi, Yang Wenjian, Crews Kristine R, Manring Christopher S, Jabbour Elias, Paietta Elisabeth, Litzow Mark R, Kornblau Steven M, Stock Wendy, Inaba Hiroto, Jeha Sima, Pui Ching-Hon, Cheng Cheng, Pruett-Miller Shondra M, Relling Mary V, Yang Jun J, Evans William E, Savic Daniel

Abstract excerpt

Defining genetic factors impacting chemotherapy failure can help to better predict response and identify drug resistance mechanisms. However, there is limited understanding of the contribution of inherited noncoding genetic variation on inter-individual differences in chemotherapy response in childhood acute lymphoblastic leukemia (ALL). Here we map inherited noncoding variants associated with treatment outcome...

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Identifiers

PMID: 38693155
DOI: 10.1038/s41467-024-48124-4
PMCID: PMC11063049

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