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Article

Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation.

Clinical immunology (Orlando, Fla.) - 1 Aug 2010

Gong Jianfeng, Xu Jingyue, Zhu Weiming, Gao Xiang, Li Ning, Li Jieshou

Abstract excerpt

Accumulating evidence suggests a role for Toll-like receptor (TLR) signaling at the intestinal epithelial cells (IECs) level for intestinal protection against exogenous injury or pathogenic infection. We hypothesized that MyD88 dependent TLR signaling at intestinal epithelium is critical for mucosal immune homeostasis. In the current study, a transgenic mouse model was generated in which a dominant-negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20452828
DOI: 10.1016/j.clim.2010.04.001

Genes

TNF

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