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Article

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function.

Infection and immunity - 1 Jan 2011

Okugawa Shu, Moayeri Mahtab, Eckhaus Michael A, Crown Devorah, Miller-Randolph Sharmina, Liu Shihui, Akira Shizuo, Leppla Stephen H

Abstract excerpt

MyD88-deficient mice were previously shown to have increased susceptibility to Bacillus anthracis infection relative to wild-type animals. To determine the mechanism by which MyD88 protects against B. anthracis infection, knockout mice were challenged with nonencapsulated, toxigenic B. anthracis or with anthrax toxins. MyD88-deficient mice had increased susceptibility to B. anthracis and anthrax lethal toxin but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20974827
DOI: 10.1128/IAI.00963-10
PMCID: PMC3019866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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