Article

An animal model for autoinflammation with infantile enterocolitis

2024-11-17

Abstract excerpt

Inflammasomes, particularly NLRC4, play a crucial role in immune responses to intracellular bacterial infections. However, gain-of-function mutations of NLRC4 are linked to severe autoinflammatory diseases, including autoinflammation with infantile enterocolitis (AIFEC). Existing mouse models do not adequately replicate the chronic, unprovoked inflammation observed in AIFEC patients. In this study, we developed a...

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Literature Corpus work: f0f4acd9-5b90-5526-ad04-1b4be0a9f248
DOI: 10.1101/2024.11.16.623944

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