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Article

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.

PloS one - 1 Jan 2016

Yoshida Takeshi, Song Lanxi, Bai Yun, Kinose Fumi, Li Jiannong, Ohaegbulam Kim C, Muñoz-Antonia Teresita, Qu Xiaotao, Eschrich Steven, Uramoto Hidetaka, Tanaka Fumihiro, Nasarre Patrick, Gemmill Robert M, Roche Joëlle, Drabkin Harry A, Haura Eric B

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is one mechanism of acquired resistance to inhibitors of the epidermal growth factor receptor-tyrosine kinases (EGFR-TKIs) in non-small cell lung cancer (NSCLC). The precise mechanisms of EMT-related acquired resistance to EGFR-TKIs in NSCLC remain unclear. We generated erlotinib-resistant HCC4006 cells (HCC4006ER) by chronic exposure of EGFR-mutant HCC4006 cells to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26789630
DOI: 10.1371/journal.pone.0147344
PMCID: PMC4720447

Genes

ZEB1
EGFR
CDH1
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.PMID 26789630Read ↗

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