Article
Inducible expression of TGFβ, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model.
Clinical & experimental metastasis - 1 Oct 2011
Argast Gretchen M, Krueger Joseph S, Thomson Stuart, Sujka-Kwok Isabela, Carey Krista, Silva Stacia, O'Connor Matthew, Mercado Peter, Mulford Iain J, Young G David, Sennello Regina, Wild Robert, Pachter Jonathan A, Kan Julie L C, Haley John, Rosenfeld-Franklin Maryland, Epstein David M
Abstract excerpt
The progression of cancer from non-metastatic to metastatic is the critical transition in the course of the disease. The epithelial to mesenchymal transition (EMT) is a mechanism by which tumor cells acquire characteristics that improve metastatic efficiency. Targeting EMT processes in patients is therefore a potential strategy to block the transition to metastatic cancer and improve patient outcome. To develop...
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