Article
Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.
Neurobiology of aging - 1 Dec 2011
Kramer Patricia L, Xu Haiyan, Woltjer Randall L, Westaway Shawn K, Clark David, Erten-Lyons Deniz, Kaye Jeffrey A, Welsh-Bohmer Kathleen A, Troncoso Juan C, Markesbery William R, Petersen Ronald C, Turner R Scott, Kukull Walter A, Bennett David A, Galasko Douglas, Morris John C, Ott Jurg
Abstract excerpt
Many elderly individuals remain dementia-free throughout their life. However, some of these individuals exhibit Alzheimer disease neuropathology on autopsy, evidenced by neurofibrillary tangles (NFTs) in AD-specific brain regions. We conducted a genome-wide association study to identify genetic mechanisms that distinguish non-demented elderly with a heavy NFT burden from those with a low NFT burden. The study...
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