Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased generation of C‐terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease

9 Feb 2018

Abstract excerpt

Increasing evidence indicates that altered reelin signaling could contribute to synaptic dysfunction in Alzheimer's disease (AD). We found that reelin protein and mRNA levels were increased in the AD brain (particularly at advanced Braak stages in apolipoprotein E4 noncarriers), compared with that of control subjects. The β‐amyloid (Aβ) protein impairs reelin activity and increases reelin expression through a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Bone Metabolism and Diseases
Share to GDF15 and Related Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29442527
DOI: 10.1096/fj.201700736rr

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased generation of C‐terminal fragments of ApoER2 and increased reelin expression in Alzheimer's diseasePMID 29442527Read ↗

The β-amyloid peptide compromises Reelin signaling in Alzheimer's disease.Semantic proximity Read ↗

The Role of Reelin Signaling in Alzheimer’s DiseaseSemantic proximity Read ↗

Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.Semantic proximity Read ↗

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.Semantic proximity Read ↗

Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loadingSemantic proximity Read ↗

Reelin signaling pathway genotypes and Alzheimer disease in a Spanish population.Semantic proximity Read ↗

LRP3, an apolipoprotein receptor that links reelin signalling and APP expression, is affected in Alzheimer's diseaseSemantic proximity Read ↗

The RELN locus in Alzheimer's disease.Semantic proximity Read ↗

Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic miceSemantic proximity Read ↗

The role of reelin gene polymorphisms in the pathogenesis of Alzheimer's disease in a Greek population.Semantic proximity Read ↗

C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.