Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers.

Journal of human genetics - 1 Jul 2010

Andoh Masataka, Sato Yasunori, Sakamoto Hiromi, Yoshida Teruhiko, Ohtaki Megu

Abstract excerpt

An association study is a popular study design to identify susceptibility genes for common complex diseases. In such a study, the presence of inappropriate samples, such as those derived from close relatives or showing DNA contamination, causes an inflation of type I error or a decrease of power. Here we propose an identity-by-state (IBS)-based detection method of inappropriate samples taking linkage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Heredity

Share to Linkage Disequilibrium

Share to Research Design

Share to ROC Curve

Share to Stomach Neoplasms

Source

Identifiers

PMID: 20448652
DOI: 10.1038/jhg.2010.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers.PMID 20448652Read ↗

Reconciling the analysis of IBD and IBS in complex trait studies.Semantic proximity Read ↗

The expected power of genome-wide linkage disequilibrium testing using single nucleotide polymorphism markers for detecting a low-frequency disease variant.Semantic proximity Read ↗

Sample size needed to detect gene-gene interactions using linkage analysis.Semantic proximity Read ↗

Which strategy is better for linkage analysis: single-nucleotide polymorphisms or microsatellites? Evaluation by identity-by-state-identity-by-descent transformation affected sib-pair method on GAW14 data.Semantic proximity Read ↗

Probabilities of two alleles being identity by state at unobserved loci predicted by observed loci in cattle populations.Semantic proximity Read ↗

The power of genome-wide association studies of complex disease genes: statistical limitations of indirect approaches using SNP markers.Semantic proximity Read ↗

A normalized identity-by-state statistic for linkage analysis of sib pairs.Semantic proximity Read ↗

Allowing for genotyping error in analysis of unmatched case-control studies.Semantic proximity Read ↗

Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects.Semantic proximity Read ↗

The Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations.Semantic proximity Read ↗

Statistical tests for detection of misspecified relationships by use of genome-screen data.Semantic proximity Read ↗

Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.