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Article

Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data.

American journal of human genetics - 1 Dec 1999

Huang J, Jiang Y

Abstract excerpt

It has been demonstrated in the literature that the transmission/disequilibrium test (TDT) has higher power than the affected-sib-pair (ASP) mean test when linkage disequilibrium (LD) is strong but that the mean test has higher power when LD is weak. Thus, for ASP data, it seems clear that the TDT should be used when LD is strong but that the mean test or other linkage tests should be used when LD is weak or...

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Identifiers

PMID: 10577929
DOI: 10.1086/302659
PMCID: PMC1288402

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