Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations.

Behavior genetics - 1 May 2017

Derks E M, Zwinderman A H, Gamazon E R

Abstract excerpt

Population divergence impacts the degree of population stratification in Genome Wide Association Studies. We aim to: (i) investigate type-I error rate as a function of population divergence (FST) in multi-ethnic (admixed) populations; (ii) evaluate the statistical power and effect size estimates; and (iii) investigate the impact of population stratification on the results of gene-based analyses. Quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FST gene
Share to Genetics, Population
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 28185111
DOI: 10.1007/s10519-017-9837-3
PMCID: PMC5403879

Genes

FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations.PMID 28185111Read ↗

Correlation of population parameters leading to power differences in association studies with population stratification.Semantic proximity Read ↗

Marbled inflation from population structure in gene-based association studies with rare variants.Semantic proximity Read ↗

Fine-scale patterns of population stratification confound rare variant association tests.Semantic proximity Read ↗

Overdispersion of allele frequency differences between populations: implications for meta-analyses of genotypic disease associations.Semantic proximity Read ↗

Most disease gene variants show minimal population differentiation despite incomplete coverageSemantic proximity Read ↗

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.Semantic proximity Read ↗

Inflated type I error rates when using aggregation methods to analyze rare variants in the 1000 Genomes Project exon sequencing data in unrelated individuals: summary results from Group 7 at Genetic Analysis Workshop 17.Semantic proximity Read ↗

Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits.Semantic proximity Read ↗

Effects of differential genotyping error rate on the type I error probability of case-control studies.Semantic proximity Read ↗

A powerful approach to test an optimally weighted combination of rare variants in admixed populations.Semantic proximity Read ↗

An empirical exploration of the (delta mu)2 genetic distance for 213 human microsatellite markers.Semantic proximity Read ↗

Critical Role of Hardy-Weinberg Equilibrium and Mixed Ethnicity to Avoid Misinterpretation in Genetic Meta-Analysis Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.