Article
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.
Circulation research - 9 Jul 2010
Butters Timothy D, Aslanidi Oleg V, Inada Shin, Boyett Mark R, Hancox Jules C, Lei Ming, Zhang Henggui
Abstract excerpt
RATIONALE: Familial sick sinus syndrome (SSS) has been linked to loss-of-function mutations of the SCN5A gene, which result in decreased inward Na(+) current, I(Na). However, the functional role of I(Na) in cardiac pacemaking is controversial, and mechanistic links between mutations and sinus node dysfunction in SSS are unclear. OBJECTIVE: To determine mechanisms by which the SCN5A mutations impair cardiac...
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