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Article

SCN5A and sinoatrial node pacemaker function.

Cardiovascular research - 1 Jun 2007

Lei Ming, Zhang Henggui, Grace Andrew A, Huang Christopher L-H

Abstract excerpt

The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells. Although iNa has been recorded from sinoatrial (SA) node pacemaker cells, its precise role in SA node pacemaker function...

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Identifiers

PMID: 17368591
DOI: 10.1016/j.cardiores.2007.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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