Article
Genetic Na+ channelopathies and sinus node dysfunction.
Progress in biophysics and molecular biology - 1 Jan 2000
Lei Ming, Huang Christopher L-H, Zhang Yanmin
Abstract excerpt
Voltage-gated Na+ channels are transmembrane proteins that produce the fast inward Na+ current responsible for the depolarization phase of the cardiac action potential. They play fundamental roles in the initiation, propagation, and maintenance of normal cardiac rhythm. Inherited mutations in SCN5A, the gene encoding the pore-forming alpha-subunit of the cardiac-type Na+ channel, result in a spectrum of disease...
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