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Article

Computational analysis of the human sinus node action potential: model development and effects of mutations.

The Journal of physiology - 1 Apr 2017

Fabbri Alan, Fantini Matteo, Wilders Ronald, Severi Stefano

Abstract excerpt

KEY POINTS: We constructed a comprehensive mathematical model of the spontaneous electrical activity of a human sinoatrial node (SAN) pacemaker cell, starting from the recent Severi-DiFrancesco model of rabbit SAN cells. Our model is based on electrophysiological data from isolated human SAN pacemaker cells and closely matches the action potentials and calcium transient that were recorded experimentally....

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Source

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Identifiers

PMID: 28185290
DOI: 10.1113/JP273259
PMCID: PMC5374121

Genes

HCN4
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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