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Article

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jun 2023

Alrabghi Ghadah, Liu Yizhou, Hu Wei, Hancox Jules C, Zhang Henggui

Abstract excerpt

Previous studies have linked dysfunctional Ito arising from mutations to KCND3-encoded Kv4.3 and KCND2-encoded Kv4.2 to atrial fibrillation. Using computational models, this study aimed to investigate the mechanisms underlying pro-arrhythmic effects of the gain-of-function Kv4.3 (T361S, A545P) and Kv4.2 (S447R) mutations. Wild-type and mutant Ito formulations were developed from and validated against experimental...

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Identifiers

PMID: 37122220
DOI: 10.1098/rstb.2022.0166
PMCID: PMC10150223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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