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Article

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation.

Stem cell reports - 8 Jun 2021

Hong Liang, Zhang Meihong, Ly Olivia Thao, Chen Hanna, Sridhar Arvind, Lambers Erin, Chalazan Brandon, Youn Seock-Won, Maienschein-Cline Mark, Feferman Leonid, Ong Sang-Ging, Wu Joseph C, Rehman Jalees, Darbar Dawood

Abstract excerpt

Mutations in SCN5A, encoding the cardiac sodium channel, are linked with familial atrial fibrillation (AF) but the underlying pathophysiologic mechanisms and implications for therapy remain unclear. To characterize the pathogenesis of AF-linked SCN5A mutations, we generated patient-specific induced pluripotent stem cell-derived atrial cardiomyocytes (iPSC-aCMs) from two kindreds carrying SCN5A mutations (E428K...

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Identifiers

PMID: 34019817
DOI: 10.1016/j.stemcr.2021.04.019
PMCID: PMC8190590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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