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Article

A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families.

Journal of molecular and cellular cardiology - 1 Jun 2005

Smits Jeroen P P, Koopmann Tamara T, Wilders Ronald, Veldkamp Marieke W, Opthof Tobias, Bhuiyan Zahir A, Mannens Marcel M A M, Balser Jeffrey R, Tan Hanno L, Bezzina Connie R, Wilde Arthur A M

Abstract excerpt

BACKGROUND: Mutations in the gene encoding the human cardiac sodium channel (SCN5A) have been associated with three distinct cardiac arrhythmia disorders: the long QT syndrome, the Brugada syndrome and cardiac conduction disease. Here we report the biophysical features of a novel sodium channel mutation, E161K, which we identified in individuals of two non-related families with symptoms of bradycardia, sinus node...

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PMID: 15910881
DOI: 10.1016/j.yjmcc.2005.02.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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