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Article

L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2015

Schmitt Ina, Kaut Oliver, Khazneh Hassan, deBoni Laura, Ahmad Ashar, Berg Daniela, Klein Christine, Fröhlich Holger, Wüllner Ullrich

Abstract excerpt

BACKGROUND: Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker. METHODS: We performed a thorough analysis of α-synuclein methylation in bisulfite-treated DNA from peripheral...

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Identifiers

PMID: 26173746
DOI: 10.1002/mds.26319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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