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α‐Synuclein Gene Hypomethylation in LRRK2 Parkinson's Disease Patients

23 Dec 2024

Abstract excerpt

BACKGROUND: α-Synuclein (SNCA) gene hypomethylation was reported in idiopathic Parkinson's disease (iPD). Based on a high clinical resemblance between iPD and leucine-rich repeat kinase 2 (LRRK2)-driven Parkinson's disease (L2PD), we investigated the epigenetic status of SNCA in an extensive LRRK2 clinical cohort from Spain. METHODS: We assessed the methylation levels of 23 CpG sites in the SNCA promoter region...

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PMID: 39711195
DOI: 10.1002/mds.30094

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