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Article

Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.

Blood - 3 May 2012

Ross Katharina, Sedello Anna K, Todd Gabriele Putz, Paszkowski-Rogacz Maciej, Bird Alexander W, Ding Li, Grinenko Tatyana, Behrens Kira, Hubner Nina, Mann Matthias, Waskow Claudia, Stocking Carol, Buchholz Frank

Abstract excerpt

The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation of hematopoietic stem and progenitor cells. However, how Runx1 orchestrates self-renewal and...

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Identifiers

PMID: 22411870
DOI: 10.1182/blood-2011-09-382390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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