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Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts

3 Feb 2014

Abstract excerpt

BACKGROUND: Polycomb group proteins form multicomponent complexes that are important for establishing lineage-specific patterns of gene expression. Mammalian cells encode multiple permutations of the prototypic Polycomb repressive complex 1 (PRC1) with little evidence for functional specialization. An aim of this study is to determine whether the multiple orthologs that are co-expressed in human fibroblasts act...

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PMID: 24485159
DOI: 10.1186/gb-2014-15-2-r23

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