Article
Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans.
Biochemistry - 5 Sept 2017
Kim Surin A, D'Acunto Victoria F, Kokona Bashkim, Hofmann Jennifer, Cunningham Nicole R, Bistline Emily M, Garcia F Jay, Akhtar Nabeel M, Hoffman Susanna H, Doshi Seema H, Ulrich Kathleen M, Jones Nicholas M, Bonini Nancy M, Roberts Christine M, Link Christopher D, Laue Thomas M, Fairman Robert
Abstract excerpt
At least nine neurodegenerative diseases that are caused by the aggregation induced by long tracts of glutamine sequences have been identified. One such polyglutamine-containing protein is huntingtin, which is the primary factor responsible for Huntington's disease. Sedimentation velocity with fluorescence detection is applied to perform a comparative study of the aggregation of the huntingtin exon 1 protein...
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