Article
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
PLoS genetics - 1 Nov 2009
Chasman Daniel I, Paré Guillaume, Mora Samia, Hopewell Jemma C, Peloso Gina, Clarke Robert, Cupples L Adrienne, Hamsten Anders, Kathiresan Sekar, Mälarstig Anders, Ordovas José M, Ripatti Samuli, Parker Alex N, Miletich Joseph P, Ridker Paul M
Abstract excerpt
While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according to class (LDL, HDL, and VLDL) and particle size (small, medium, and large). The concentrations of these lipoprotein sub-fractions may be related to risk of cardiovascular disease and related...
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